Honestly? The easiest fix is to just install Windows on a separate partition. I know, I hate saying it. But Dead Space 3 is an older game that runs on a potato. You don't need a VM for it. If you have a spare 50GB SSD, just dual boot. You will spend less time fighting the DRM than you will debugging the VM settings.
Modern Windows features like Core Isolation or Virtual Machine Platform (often used for WSL2 or Android apps) run in a virtualized container that the game may detect. Honestly
Why would Dead Space 3 care? The answer is almost entirely . Honestly
The "Sorry, this application cannot run under a virtual machine" error in Dead Space 3 Honestly